Chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD) Respiratory
Conditions
Interventions
Participants will undergo the following assessments for suitability for bronchoscopy: spirometry, DLCO (ILD patients only), physical examination, oxygen saturations via a pulse oximeter, blood samplin
Sponsors
Medicines Evaluation Unit
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Must be aged over 18 years, be competent to understand and give informed consent 2. Participants with asthma, COPD and ILD must have stable disease with no exacerbations or infections for at least 6 weeks prior to bronchoscopy Participants with asthma must have: 1. Clinically diagnosed asthma 2. Forced Expiratory Volume in 1 Second (FEV1) >30% predicted 3. FEV1 > 1.0 litre; participants with FEV1 >30% predicted but 30% predicted 3. FEV1 >1.0 L; participants with FEV1 >30% predicted but 35% predicted 2. Forced Vital Capacity (FVC) >45% predicted 3. Oxygen saturation above 90% on room air Healthy participants must have: 1. No history of a chronic respiratory disorder 2. No history of acute respiratory disease within 6 weeks prior to bronchoscopy 3. No other significant medical disorder that may affect the respiratory system or that causes significant disability Healthy participants who are smokers must: 1. Be current or ex-cigarette smokers with a smoking history of at least 10 pack-years 2. Have FEV1 >90% predicted Healthy participants who are non-smokers must have: No significant smoking history as judged by the investigator
Exclusion criteria
Exclusion criteria: All participants: 1. History of any other inflammatory lung condition or carcinoma of the lung 2. Participants who are taking warfarin or have any bleeding disorders 3. Women who are pregnant or breastfeeding Participants with respiratory conditions: 1. Exacerbation of disease requiring hospitalisation within previous 6 months 2. History of ITU admission secondary to asthma, COPD or ILD 3. Use of home oxygen for COPD or ILD
Countries
England, United Kingdom
Contacts
Public ContactNatalie Jackson
Outcome results
None listed