Patients admitted to be operated for major abdominal surgery, i.e. duodeno-cephalo-pancreasectomy, total mesorectal excision, total and partial nephrectomy, total and partial gastrectomy, debulking for ovarian tumeur, total cystectomy. Surgery
Conditions
Interventions
Participants were randomly assigned to one of two groups in a 1:1 ratio, based on Efron’s biased coin randomisation procedure generated with NCSS v10 Statistical Software (2015, NCSS, Llc. Kaysville,
Sponsors
Erasmus Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 18 years old 2. Planned major abdominal surgery: duodeno-cephalo-pancreasectomy, total mesorectal excision, total and partial nephrectomy, total and partial gastrectomy, debulking for ovarian tumour, total cystectomy
Exclusion criteria
Exclusion criteria: 1. Urgent surgery 2. Severe heart conduction block without implantable pacemaker 3. Severe liver and kidney insufficiency 4. Major liver resection 5. Acute heart failure 6. Allergic reaction to lidocaine or other amide-linked local anesthetics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Syndecan-1 concentration measured by classic sandwich enzyme-linked immunosorbent assay at baseline (before surgery), 1-3 h post surgery and 24 h | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. StO2-baseline, StO2-ischemic slope and StO2-reperfusion slope measured using near-infrared spectroscopy on thenar eminence, before during and after a vascular occlusion test, at baseline (before surgery), 1-3 h post surgery and 24 h 2. Brachial artery baseline diameter, maximal flow-mediated dilation and area under the curve of estimated shear rate of hyperaemic flow measured by ultrasonography of the brachial artery coupled with an automated edge detection software, before during and after a vascular occlusion test, at baseline (before surgery), 1-3 h post surgery and 24 h | — |
Countries
Belgium
Outcome results
None listed