Urinary tartaric acid as a sensitive dietary biomarker of moderate wine consumption

Use of urinary concentration of tartaric acid as a dietary biomarker of red and white wine: an open randomized cross-over controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN63399546

Enrollment

Registered

2013-05-09

Start date

2012-07-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Concentration of tartaric acid in urine Not Applicable

Interventions

Intervention 1: Administration of 100 ml red wine (10.3 g ethanol). Intervention 2: Administration of 200 ml red wine (20.5 g ethanol). Intervention 3: Administration of 300 ml red wine (30.8 g ethano

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy adults, males, 18-50 years

Exclusion criteria

Exclusion criteria: 1. Previous history of cardiovascular disease (ischemic heart disease - angina or recent or old myocardial infarction, cerebral vascular accident, or peripheral vascular disease) 2. Homeostatic disorders 3. Any several chronic diseases 4. Hypertension or dislipemia 5. Smoking subjects 6. Alcoholism 7. Other toxic abuse

Design outcomes

Primary

Measure	Time frame
Concentrations of urinary tartaric acid will be determined by liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). These determinations will be carried out in first morning urines collected the day before the first intervention and in the morning following each intervention. Creatinine adjustment was used to normalize analyze concentrations in these urine samples. Urinary concentration of tartaric acid was measured at day 7 (before first intervention), at day 8 (10 hours after first intervention), at day 14 (before second intervention), at day 15 (10 hours after second intervention), at day 21 (before third intervention) and at day 22 (10 hours after third intervention).	—

Measure

Time frame

Concentrations of urinary tartaric acid will be determined by liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). These determinations will be carried out in first morning urines collected the day before the first intervention and in the morning following each intervention. Creatinine adjustment was used to normalize analyze concentrations in these urine samples. Urinary concentration of tartaric acid was measured at day 7 (before first intervention), at day 8 (10 hours after first intervention), at day 14 (before second intervention), at day 15 (10 hours after second intervention), at day 21 (before third intervention) and at day 22 (10 hours after third intervention).

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Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026