Severe burns - acute Injury, Occupational Diseases, Poisoning Burn and corrosion, body region unspecified
Conditions
Interventions
This is an intra-patient study (each patient will act as their own control) and each patient will receive all the treatment regimes under investigation i.e. Cryopsray, ReCell and standard care.
Stand
Sponsors
Queen Mary University London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who are 18 years old at least 2. Patient is in good general health 3. Patient is willing and able to co-operate with the protocol for the duration of the study 4. Patients with a donor graft site due to requiring a split skin graft to treat a large burn 5. Patients able to give written consent
Exclusion criteria
Exclusion criteria: 1. Patients unable to give written consent 2. Terminally ill patients 3. Pregnant women 4. Patients with skin disorders that may affect the growth of cells or subsequent wound healing e.g. patients on high concentrations of steroids, patients with psoriasis or eczema 6. Patient has a history of hypersensitivity to any components of either Cryoskin Spray (e.g. DMSO) or ReCell (trypsin) 7. Patients with eczema; genetic skin conditions; hypertrophic or keloid scars
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective measures of wound healing via punch biopsy analysis (time course of cytokine and growth factor expression) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time to complete wound closure (100% re-epithelialisation) 2. Aesthetic outcome of burn site via Derriford Appearance Scale and Patient and Observer Scar Assessment Scale (POSAS) at week 4, 8, 12 and 24 | — |
Countries
United Kingdom
Outcome results
None listed