Effect of endometrial injury on repeat implantation failure following in vitro fertilization embryo transfer or frozen embryo transfer

Effect of endometrial injury on repeat implantation failure following in vitro fertilization embryo transfer or frozen embryo transfer: a randomized controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN63112626

Enrollment

400

Registered

2012-04-12

Start date

2011-11-05

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility Pregnancy and Childbirth Female infertility

Interventions

Endometrium scratching in fifth day after ovulation prior to an IVF or FET cycle in study group. No extra administration prior to an IVF or FET cycle in control group Control group: patients with RI

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Patients with repeated implantation failure (three or more) undergoing in vitro fertilization embryo transfer (IVF-ET) or frozen embryo transfer (FET) 2. Patients with normal preoperative routine checks 3. Patients aged 40 years old or younger with basal follicle-stimulating hormone (FSH)5 in hibateral ovaries 4. Patients without history of uterine cavity operation in two months

Exclusion criteria

Exclusion criteria: 1. Patients with hydrosalpinx 2. Patients with history of endometrium adhesion 3. Patients with uterine malformation 4. Patients with acute genital tract inflammation 5. Patients with history of using hormone such as oral contraceptive in three months

Design outcomes

Primary

Measure	Time frame
1. Implantation rate 2. Clinical pregnancy rate defined as the presence of a fetal sac by ultrasound scanning	—

Secondary

Measure	Time frame
1. Endometrial thickness 2. Endometrial type 3. Blood flow under endometrium	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026