VITAL: a trial looking at which general anaesthesia technique is better for patient recovery following major non-cardiac surgery

Conditions

Total intravenous anaesthesia (TIVA) compared to inhalational volatile-based anaesthesia Surgery

Shaman Jhanji, Katie Booth, Louise Hiller, John Braun, Janet Dunn et al. (100 authors)

JAMA2026-08-121 citations

10.1001/jama.2026.11065

Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL).

Yeung J, Jhanji S, Braun J, Dunn J, Eggleston L, Frempong S, Hiller L, Jacques C, Jefford M, Mason J, Moonesinghe R, Pearse R, Shelley B, Vindrola C, VITAL trial team.

2024-06-274 citations

10.1186/s13063-024-08159-w

Comparison between propofol and total inhalational anaesthesia on cardiovascular outcomes following on-pump cardiac surgery in higher-risk patients: a randomised controlled pilot and feasibility study

Benjamin Milne, Martin John, Richard D. Evans, Steven Robertson, Pádraig Ó Scanaill et al. (10 authors)

Open Heart2024-05-015 citations

10.1136/openhrt-2024-002630

Interventions

VITAL is a multi-centre pragmatic efficient randomised controlled trial with health economic analysis. A 6-month internal pilot phase will seamlessly run into the main trial, on the condition that the

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age >=50 years 2. Elective major non-cardiac surgery under general anaesthesia (as per PQIP inclusion criteria) 3. Written informed consent for trial participation

Exclusion criteria

Exclusion criteria: 1. Known contraindication to either TIVA or inhalational anaesthesia 2. Clinician refusal 3. Procedures where the participant is not expected to survive for 30 days 4. Previous participation in VITAL trial 5. Patient unable to give informed consent or complete questionnaires

Design outcomes

Primary

Measure	Time frame
Days alive and at home at 30 days (DAH30) measured using patient records	—

Secondary

Measure	Time frame
1. Days alive and at home at 90 days (DAH90) measured using patient records 2. 30-Day and 90-Day and six-month mortality measured using patient records 3. Quality of recovery after anaesthesia (QoR-15) day 3 post-op 4. Patient satisfaction with anaesthesia (Bauer questionnaire) day 1 post-op. 5. Awareness under anaesthesia measured using the Brice questionnaire day 3 and day 30 post-op.	—

Countries

United Kingdom

Contacts

Public ContactClaire Jacques

VITAL@warwick.ac.uk+44 (0)2476 522566

Outcome results

None listed