Knee extensor muscle strength/functional capacity in older women Musculoskeletal Diseases
Conditions
Interventions
The subjects will participate in a strength training programme three times a week, lasting 60-minute each session, for 10 weeks. Two major muscle groups (knee extensors and flexors) will both be train
Sponsors
National Council of Scientific and Technological Development (CNPq) (Brazil)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female 2. Community-dwelling 3. Aged equal to or higher than 65 years-old 4. Classified as pre-frail according to the phenotype
Exclusion criteria
Exclusion criteria: 1. Elderly previously submitted to orthopedic surgeries on lower limbs and/or with a history of fracture 2. Those whom were not able to walk without support 3. Carriers of neurological diseases 4. Those whom presented any type of inflammatory disease in an acute stage 5. Neoplasia in activity in the last five years 6. Those whom were using medication that affect largely the immunological system 7. Those whom presented cognitive impairments detectable by the Mini-Mental State Examination (MMSE)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma levels of IL-6 and TNF-alpha measured by enzyme-linked immunosorbent assay. All primary and secondary outcomes will be assessed at baseline (before intervention), after intervention and 10 weeks post-intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Static and isokinetic muscle strength of the knee extensors and flexors measured electronically by Byodex 3 Pro (Biodex Medical System, USA) 2. Functional capacity, measured by the 10-meter walk test and the Timed Up and Go test (TUG) 3. Clinical outcomes (pain, fatigue and self-perceived health) All primary and secondary outcomes will be assessed at baseline (before intervention), after intervention and 10 weeks post-intervention. | — |
Countries
Brazil
Outcome results
None listed