Efficiency of 7.2% hypertonic saline hydroxyethyl starch 200/0.5 versus mannitol 15% in the treatment of increased intracranial pressure in neurosurgical patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN62699180

Enrollment

Registered

2005-06-24

Start date

2003-02-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Increased intracranial pressure Nervous System Diseases Brain edema

Interventions

Cerebral perfusion pressure (CPP) directed therapy with CPP >70 mmHg, sedation, normoventilation. If ICP >20 mmHg patients receive either 7.2% hydroxyethyl starch 200/0.5 or mannitol 15%.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Neurosurgical patients >18 years with severe neuronal damage being at risk of increased intracranial pressure (ICP) 2. Cerebral edema - visualized by computed tomography (CT) scan, continuous monitoring of ICP

Exclusion criteria

Exclusion criteria: Exclusion criteria were elevated ICP due to space occupying lesions with indication for neurosurgical intervention, severe renal failure, metabolic disorders, initial serum sodium >150 mmol/l and initial serum osmolarity >320 mosm/kg

Design outcomes

Primary

Measure	Time frame
ICP <15 mmHg	—

Secondary

Measure	Time frame
Survival, discharge status	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 23, 2026