Assessing the effects of smell training on the brains of patients with an impaired sense of smell after surgery

Neuroplasticity assessment using fMRI after olfactory training in post-surgical olfactory impaired patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN62670142

Enrollment

Registered

2020-06-02

Start date

2017-10-01

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-surgical olfactory dysfunction Ear, Nose and Throat

Interventions

All participants undergo an olfactory measurement test to diagnose olfactory dysfunction and assess severity. Also, they are examined by an ENT specialist's including a complete physical exam and naso

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Referred post-surgical olfactory dysfunction lasting for at least 1 year 2. Only patients with a definite diagnosis of olfactory dysfunction were finally included 3. No history of psychiatric or neurodegenerative diseases

Exclusion criteria

Exclusion criteria: 1. Olfactory dysfunction not related to surgical procedures 2. Associated psychiatric or neurodegenerative diseases 3. Pediatric age

Design outcomes

Primary

Measure	Time frame
Activation areas and functional connectivity during olfactory stimulation measured using functional MRI images before olfactory training and 12 weeks after the intervention	—

Secondary

Measure	Time frame
Olfactory function assessed using olfactometric measurements before olfactory training and 12 weeks after the intervention	—

Countries

Chile

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026