Epigastric pain with normal or altered endoscopy Digestive System
Conditions
Interventions
100 peptic ulcer or functional dyspepsia patients randomized to two eradication regimens - two arms Helicobacter pylori eradication study:
1. Amoxicillin + clarithromycin + lansoprazol
Sponsors
Hospital das Clínicas da Faculdade de Medicina da USP (Brazil)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Outpatients with organic or functional dyspepsia 2. Aged between 18 and 80 years 3. Helicobacter pylori diagnosis confirmed by histology, rapid urease test or urea breath test (UBT) 4. No previous eradication history 5. Patients need to sign and understand the informed consent term
Exclusion criteria
Exclusion criteria: 1. Chronic or regular use of anabolic androgenic steroids (AAS) or non-steroidal anti-inflammatory drug (NSAID) 2. Recent antibiotic use (at least 30 days) before the study inclusion or before eradication control 3. Complicated peptic ulcer (Forrest I, Forrest II), bulbar stenosis 4. Pregnant or breastfeeding women 5. Previous gastric surgery 6. Consumptive renal, cardiac, hepatic insuficiency diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Eradication rates 2. Cure rates will be achieved by endoscopy or UBT performed two months after the end of the treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects are assessed by a questionnaire at the final visit | — |
Countries
Brazil
Outcome results
None listed