Chronic cough and gastro-oesophageal reflux disease. Signs and Symptoms Gastro-oesophageal reflux disease
Conditions
Interventions
The subject will attend 5 visits, as described below:
Visit 1: Lung Function
1.1. Symptom questionnaires (Subjective cough scores, cough quality of life, reflux symptom scores and quality of life)
1
Sponsors
University Hospital of South Manchester (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Males and Females over 18 yrs of age 2. Chronic dry cough for more than 8 weeks duration 3. Normal chest x-ray 4. Normal lung function
Exclusion criteria
Exclusion criteria: 1. Upper Respiratory Tract Infection within last 4 weeks 2. Current smokers 3. Pregnancy 4. Opiate medication / ACE Inhibitor use 5. Diabetes Mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Allocation of patient to one of 3 classifications using results from the above procedures: 1. Negative group (no evidence of reflux disease as determined by oesophageal studies) 2. Distal Reflux acid/non-acid as determined by oesophageal studies 3. Proximal Reflux acid/non-acid as determined by oesophageal studies | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Evidence of aspiration in three groups as determined by study of bronchoscopy samples 2. Evidence of dysmotility in three groups 3. Severity association between cough and reflux events as determined by cough monitoring and questionnaires 4. Comparison of acid and non-acid reflux 5. Comparison of cough rates with and without the oesophageal | — |
Countries
United Kingdom
Outcome results
None listed