Rheumatoid arthritis (RA) Musculoskeletal Diseases Seropositive rheumatoid arthritis
Conditions
Interventions
The intervention group will participate in strength training three times a week in a 75-minute training program for 12 weeks. Eight major muscle groups will each be trained in three sets of eight repe
Sponsors
ALF Foundation (Sweden)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Twenty female patients after menopause 2. RA according to American College of Rheumatology criteria 3. Less than 12 months since diagnosis 4. Stable medication since at least three months 5. Independent in daily living 6. Passed menopause 7. Speak and understand Swedish 8. No other major disease that prevent them from performing intensive strength training
Exclusion criteria
Exclusion criteria: Does not comply with the above inclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Static and isokinetic muscle strength in knee extensors and knee flexors measured electronically with the Kin-Com. Both the primary and the secondary outcomes will be measured at baseline and at three month follow up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical outcome (body functions, pain, fatigue and perceived health) 2. Inflammation 3. Pain mechanisms 4. Comorbidity 5. Muscle biopsies from vastus lateralis analysed for reactive oxygen species/reactive nitrogen species and expression of oestrogen receptors in muscles from patients with RA patients and controls before and after the intervention Both the primary and the secondary outcomes will be measured at baseline and at three month follow up. | — |
Countries
Sweden
Outcome results
None listed