Brain cancer Cancer
Conditions
Interventions
When the patient attends for their radiotherapy planning MRI scan, they will undergo the conventional imaging sequences as per the standard of care and, during this scan, they will also undergo additi
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age of 18 years or above on the day of recruitment 2. Have one or more brain metastases from an extracranial primary solid malignancy 3. Accepted for stereotactic radiosurgery to one or more brain metastases following discussion at the local SRS MDT 4. Must have never received any form of prior radiotherapy to the brain
Exclusion criteria
Exclusion criteria: 1. Age < 18 years old at the time of eligibility screening 2. Patient has received prior radiotherapy to the brain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Baseline perfusion characteristics of host cerebral vascular environment (measured in rCBV on MRI) 2. Baseline perfusion characteristics of brain metastases from a selection of primary sites (measured in rCBV on MRI) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlation between baseline perfusion characteristics of brain metastases and primary site of malignancy (descriptive stats – correlation coefficient) 2. Inter-tumour variability in baseline perfusion characteristics in patients with more than one brain metastasis (descriptive stats) Exploratory: 3. To identify patients with suspected radionecrosis during data collection phase 1 and analyse baseline perfusion characteristics with a view to identifying possible risk associations – measured in follow-up period up to 2 years (descriptive) | — |
Countries
England, United Kingdom
Outcome results
None listed