Prevention of hypertension in normotensive to pre-hypertensive adults through isometric exercise training Circulatory System
Conditions
Interventions
All participants are randomly assigned using stratified random allocation to one of five groups. During the first 4 weeks, all intervention groups complete isometric wall squat training three times pe
Sponsors
Canterbury Christ Church University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male and female participants with normal to high-normal sBP (range 120-140 mmHg) 2. University staff and students from Canterbury Christ Church University and their associates via social media and word of mouth 3. Total weekly physical activity level below the 150 minutes of moderate physical activity per week, or specifically =600 MET-minutes, calculated as the sum of all light-intensity activities (light walking = 3.3 METs, light cycling = 3.0 METs, household work = 2.5 METs). Total MET-minutes were computed as MET × duration (min). To exclude structured exercise, any reported bout =4 METs lasting = 10 minutes (e.g. jogging and weight training) led to exclusion. 4. Free from any injuries or illnesses 5. Not taking any medication (or had previously taken any anti-hypertensive medication) 6. Non-smokers 7. Consumed less than 14 units of alcohol per week 8. Screening was conducted using a standard Physical Activity Readiness Questionnaire 9. Provided written informed consent
Exclusion criteria
Exclusion criteria: 1. Free from any injuries or illnesses 2. Not taking any medication (or had previously taken any anti-hypertensive medication) 3. Non-smokers 4. Consumed less than 14 units of alcohol per week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting systolic blood pressure (SBP) is measured using the Task Force® Monitor during a 5-minute seated continuous recording at baseline, week 4, and week 8 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mean arterial pressure (MAP) is calculated from continuous blood pressure data recorded by the Task Force® Monitor during a 5-minute seated period at baseline, week 4, and week 8 2. Diastolic blood pressure (DBP) is measured using the Task Force® Monitor during the same 5-minute seated recording at baseline, week 4, and week 8 3. Total peripheral resistance (TPR) is derived from concurrent blood pressure and cardiac output signals via the Task Force® Monitor during a 5-minute seated measurement at baseline, week 4, and week 8 4. Cardiac output (Q?) and stroke volume (SV) are recorded via impedance cardiography using the Task Force® Monitor during a 5-minute seated recording at baseline, week 4, and week 8 5. Heart rate variability (HRV) metrics (LF, HF, LFnu, HFnu, LF/HF ratio) are calculated from ECG data obtained via the Task Force® Monitor during the 5-minute seated period at baseline, week 4, and week 8 6. Baroreflex sensitivity (BRS) is assessed using sequence and spectral methods applied to the 5-minute continuous Task Force® Monitor data at baseline, week 4, and week 8 | — |
Countries
England, United Kingdom
Contacts
Public ContactJim Wiles
Outcome results
None listed