The effects of high fat meals enriched with n-3 fatty acids on blood pressure at rest & during exercise

The acute effects of high fat meals enriched with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) versus oleic acid on cardiac output and other cardiovascular haemodynamics at rest and during dynamic exercise in healthy young men

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN62232400

Enrollment

Registered

2010-10-27

Start date

2008-01-28

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular disease Circulatory System Heart disease

Interventions

A randomised, crossover intervention study to investigate the effects of high-fat meals (50g fat) containing high-oleic sunflower oil enriched with 5 g of either EPA or DHA, compared to a control high

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy men, aged 18 - 45 years

Exclusion criteria

Exclusion criteria: 1. Current smokers or those smoked in the past 6 months 2. Consumption of more than a portion of oily fish per week and/or regular fish oil supplementation within the past 3 months 3. Body mass index less than 18.0 and greater than 30 kg/m2 4. Seated blood pressure of or greater than 140/90mmHg 5. Plasma total cholesterol > 7.8 mmol/L; 6. Plasma triacylglycerol (TAG) >3.0 mmol/L; 7.Diabetes mellitus (fasting plasma glucose >7.0 mmol/L) 8. Abnormal haematology or liver function tests 9. Self-reported history of myocardial infarction, angina, venous thrombosis, stroke, cancer 10. Presence of gastrointestinal disorder or use of a drug, which is likely to alter gastrointestinal motility or nutrient absorption 11. Self-reported weekly alcohol intake of > 28 standard units of alcohol (1 unit = 10 mL ethanol) 12. Systematic use of any kind of drug or prescribed blood pressure anti-inflammatory or blood-thinning medication

Design outcomes

Primary

Measure	Time frame
Blood pressure (with heart rate and cardiac output), was measured at baseline (before the meal), and then 1, 2, 3 and 5 h after the meal, then at 3, 6 9 and 12 min during the 12-min multi-stage cycling protocol of moderate intensity. Then the subjects were allowed to recover from the exercise in a seated position and further measurements of blood pressure, heart rate and cardiac output were determined at 15, 30 and 45 min post-exercise.	—

Measure

Time frame

Blood pressure (with heart rate and cardiac output), was measured at baseline (before the meal), and then 1, 2, 3 and 5 h after the meal, then at 3, 6 9 and 12 min during the 12-min multi-stage cycling protocol of moderate intensity. Then the subjects were allowed to recover from the exercise in a seated position and further measurements of blood pressure, heart rate and cardiac output were determined at 15, 30 and 45 min post-exercise.

—

Secondary

Measure	Time frame
1. A change in arterial stiffness as measured by digital volume pulse (DVP) (stiffness index [SI] and reflection index [RI]) at baseline (before the meal), and then 1, 2, 3 and 5 h after the meal, and then 15, 30 and 45 min post-exercise (after the 12 min cycling protocol). Blood samples were taken for plasma isoprostanes analysis at baseline (before the meal), and then 5 h after the meal, and then immediately post-exercise (after the 12 min cycling protocol). 2. A change in 8-isoprostane-F2alpha concentrations as an index of oxidative stress	—

Measure

Time frame

1. A change in arterial stiffness as measured by digital volume pulse (DVP) (stiffness index [SI] and reflection index [RI]) at baseline (before the meal), and then 1, 2, 3 and 5 h after the meal, and then 15, 30 and 45 min post-exercise (after the 12 min cycling protocol). Blood samples were taken for plasma isoprostanes analysis at baseline (before the meal), and then 5 h after the meal, and then immediately post-exercise (after the 12 min cycling protocol). 2. A change in 8-isoprostane-F2alpha concentrations as an index of oxidative stress

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026