Acute myocardial infarction (MI) Circulatory System Acute myocardial infarction (MI)
Conditions
Interventions
Not provided at time of registration
Sponsors
Medical Research Council (MRC) (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Post menopausal women (amenorrhoea for more than 12 months oestrogen deficiency symptoms) or more than 55 years, more than 48 hours and less than 7 days after the onset of acute Myocardial Infarction (MI) (Creatine Kinase [CK] twice upper limit or CKMB above the threshold considered diagnostic for myocardial damage in that centre) plus one of the two additional following criteria: 1. Admission for symptoms of acute myocardial ischaemia 2. Changes on the electrocardiogram supportive of a diagnosis of acute MI, provision of written informed consent
Exclusion criteria
Exclusion criteria: 1. Unconfirmed MI 2. Use of HRT currently or previous 12 months, patients for whom clear indications for, of contraindications to, long term HRT 3. Increased risk of thromboembolism 4. Prior history of DVT or PE 5. BMI more than 32 6. Prolonged immobility 7. Known breast or endometrial cancer 8. Post-menopausal bleeding that has not been adequately investigated 9. Presence of non-cardiac condition influencing survival 10. Anticipated inability of the patient to comply with the study procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reinfarction, readmission, death | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed