Loxoprofen versus diclofenac potassium in post-dental extraction pain relief and side effects

Roxonin versus Rabidus in post-dental extraction pain relief and side effects: a randomized, triple-blind, controlled clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN62004181

Enrollment

100

Registered

2019-11-05

Start date

2018-01-20

Completion date

Unknown

Last updated

2023-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after tooth extraction Oral Health

Interventions

Eligible patients after tooth extraction were randomized to the study interventional groups (Rapidus or Roxonin) by means of drawing lots and intervention and control were coded as A or B. The codes

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18-70 years old . 2. Literate people (speaking, reading and writing Arabic or English). 3. Healthy or with controlled systemic disease as recommended by the American Society of Anesthesiologists and had no risk from the administration of LA with adrenaline (hyperthyroidism).

Exclusion criteria

Exclusion criteria: 1. Could not give informed consent (e.g. mental disorder) 2. Teeth with reversible pulpitis 3. History of taking anticoagulant, active peptic ulcer and attack of asthma

Design outcomes

Primary

Measure	Time frame
Pain after tooth extraction by using VAS (visual analogue scale) , the timepoint was after 6 hours of tooth extraction and every 12 hours for three days.	—

Secondary

Measure	Time frame
Side effects over the trial period (three days)	—

Countries

Saudi Arabia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026