Obstructive sleep apnoea syndrome (OSAS) Nervous System Diseases Obstructive sleep apnoea
Conditions
Interventions
1. An early CPAP group: CPAP + best supportive care (BSC) for 12 weeks
2. A delayed CPAP group: BSC for 6 weeks initially then CPAP + BSC will be combined for another 6 weeks.
BSC includes normal m
Sponsors
Kaohsiung Medical University Hospital (Taiwan)
Department of International Cooperation (Taiwan)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 60 years and over 2. Have apnoea-hypopnoea index (AHI) = 15 3. Nap at least 3 times per week with average nap duration of at least 30 minutes
Exclusion criteria
Exclusion criteria: 1. Have previous exposure to continuous positive airway pressure (CPAP) therapy 2. Are unable to give written informed consent or comply with the protocol 3. Are on central nervous system (CNS)-active drug treatment (e.g., hypnotic and antiepileptic drugs) that causes significant daytime sleepiness or cognitive impairment 4. Have an unstable medical or psychiatric illness 5. Have moderate to severe respiratory disease that affects activities of daily living or awake SpO2 less than 92%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in weekly nap frequency and duration every 6 weeks in both groups | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. CPAP compliance during CPAP intervention in both groups 2. Change in Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) scores 3. Change in RAND-36 scores 4. Change in Hospital Anxiety and Depression Scale (HADS) scores Measured every 6 weeks in both groups 5. Change in reaction time of Psychomotor Vigilance Task (PVT) assessed post intervention | — |
Countries
Taiwan, United Kingdom
Outcome results
None listed