Improving B vitamin biomarkers Nutritional, Metabolic, Endocrine
Conditions
Interventions
Participants are randomised by block randomisation to one of two groups:
1. Intervention group receive a 200 ml drink manufactured to contain 200 µg folic acid, 10 µg vitamin B12, 10 m
Sponsors
University College Dublin
University of Ulster
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Free-living adults 2. Aged 50 years and over 3. Consumption of four or less portions of fortified food per week 4. Did not currently or had not in the previous 4 months consumed a supplement containing B vitamins
Exclusion criteria
Exclusion criteria: 1. Diagnosis of coeliac disease, Crohn’s disease, ulcerative colitis, liver disease (NAFLD and hepatitis) or chronic obstructive pulmonary disease 2. Medication known to interfere with B vitamin metabolism 3. Women taking hormone replacement therapy, pregnant or lactating 4. Taking part in another research 5. Unable to give informed consent to take part
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. B vitamin biomarker concentrations measured at baseline and 16 weeks: 1.1. Riboflavin measured by erythrocyte glutathione reductase activation coefficient assay (EGRac) 1.2. Serum folate concentrations measured by a microbiological assay based on a chloramphenicol-resistant strain of Lactobacillus casei 1.3. Serum vitamin B12 determined by microbiological assay using Lactobacillus leichmanni 1.4. Homocysteine measured by fluorescence polarisation assay | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at baseline and at 16 weeks: 1. Vitamin D measured as 25-hydroxyvitamin D using liquid chromatography – mass spectrometry (LC–MS) 2. Anthropometric variables: weight measured on a scale, BMI calculated, systolic and diastolic blood pressure measured using an Omron 705IT monitor | — |
Countries
Ireland, Northern Ireland, United Kingdom
Contacts
Public ContactLorraine Brennan
Outcome results
None listed