Mild to moderate asthma in acute exacerbation Respiratory Asthma
Conditions
Interventions
Chinese herbs arm: Chinese herbs and beta-2-agonists (salbutamol), systemic steroids (0.5 - 1 mg/kg) if necessary.
Placebo arm: placebo and beta-2-agonists (salbutamol), systemic steroids (0.5 - 1 mg
Sponsors
West China Hospital at Sichuan University (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Mild to moderate asthma in acute exacerbation 2. Male and female patients between 15 and 75 years 3. Within 72 hours of onset of acute asthma 4. Ability to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Use of systemic steroids or immunosuppressive agents within one month before recruitment, or history of life-threatening asthma requiring treatment with intubation and mechanical ventilation 2. Maintenance therapy with symbicort, or rescue therapy with formoterol or anticholinergic agents 3. Allergies to any components Yi-Qi-Pin-Chuan granule, as Chinese medicine 4. Current alcoholism or drug abuse 5. Lung diseases other asthma 6. Severe diseases of cardiovascular, hepatic, renal, central nervous system, haematopoietic system cancer 7. Significant medical illness (other than asthma) that is not stable 8. History of respiratory tract infection within the previous 6 weeks 9. Pregnancy or breastfeeding 10. The inability to understand and complete this study 11. Peptic ulcer or gastrointestinal haemorrhage 12. Intolerance to beta-2-agonists or steroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patients with use of systemic steroids and steroid dose, evaluated at days 4 and 8 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The number of patients with hospital admissions, evaluated at days 4 and 8 2. The number of puffs of beta agonists (salbutamol), recorded in asthma diary by the patient 3. Lung functions (PEF), assessed at hours 0, 2, 4, 6, 8, 10, 12 after recruitment, and in morning and evening every day during 7 days of treatment | — |
Countries
China
Outcome results
None listed