Chronic obstructive pulmonary disease (COPD) with secondary pulmonary hypertension Respiratory Other chronic obstructive pulmonary disease
Conditions
Interventions
In every of the three study visits the patient will inhale one of the following in a randomised manner prior to the exercise test:
1. 0.9% saline (2 ml)
2. 10 µg iloprost diluted in 0.9% saline (2 ml
Sponsors
University Hospital Basel (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with diagnosed COPD (Global initiative for chronic Obstructive Lung Disease [GOLD] I - IV) 2. Confirmed disproportional pulmonary arterial hypertension (mean pulmonary artery pressure of over 45 mmHg during exercise and/or over 30 mmHg at rest) 3. Aged above 40 years, men and women
Exclusion criteria
Exclusion criteria: 1. Mental disorder preventing appropriate judgment concerning study participation 2. Significant comorbidity resulting in reduced life expectancy (lower than 6 months) 3. Significant exacerbation of COPD within the last month 4. Decompensated heart failure (left ventricular ejection fraction below 30%) 5. Present pulmonary embolism 6. PH explained by another cause than COPD 7. Pregnant and breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six-minute walking distance (6MWD) test, measured during the three study visits, after every inhalation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured during the three study visits, after every inhalation: 1. Oxygen consumption 2. Oxygen saturation 3. Ventilation 4. Carbon dioxide production 5. Arterial oxygen content 6. Alveolar-arterial gradient 7. BORG score | — |
Countries
Switzerland
Outcome results
None listed