Surgery: Coronary artery bypass grafting (CABG) Surgery Coronary artery bypass grafting (CABG)
Conditions
Interventions
Patients will be recruited from the cohort of the 4 surgeons at the Cardiothoracic Unit in Castle Hill Hospital. Patients will be recruited at the Out-Patients Clinic and on the ward prior to surgery
Sponsors
Department of Health
Eligibility
Inclusion criteria
Inclusion criteria: Patients will be recruited from the cohort of the 4 surgeons at the Cardiothoracic Unit in Castle Hill Hospital.
Exclusion criteria
Exclusion criteria: 1. Asthma 2. Known intolerance to N acetyl cysteine 3. Serum creatinine greater than 200 mol/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demonstration of anticipated enhanced protective effect of hyperbaric preconditioning in the heart biopsies as determined by 1. Elevated levels of cellular HSP 72 mRNA, HSP 72 protein 2. Elevated levels of cellular iNOS mRNA, iNOS protein, eNOS mRNA, eNOS protein and total cellular Nitric Oxide 3. Reduced ischemic reperfusion injury as determined by reduced levels of P-selectin, TNF-ALPHA, IL-6 and IL-8 and its mRNA ie. P-selectin mRNA, TNF-ALPHA mRNA, IL-6 mRNA and IL-8 mRNA | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed