Critically Ill Patients with Acute Lung Injury (ALI) Respiratory Acute lung injury (ALI)
Conditions
Interventions
Control Ventilation Strategy (assist control
low airway pressures
standard PEEP)
Experimental Lung Open Ventilation Strategy (pressure control
low tidal volumes
recruitment maneuvers).
For further information, please contact Dr Meade at the address listed below or Dr Thomas Stewart at University of Toronto (tstewart@mtsinai.on.ca).
Sponsors
McMaster University (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Persons of either sex 18 years and older. 1. Invasive mechanical ventilation 2. Acute respiratory insufficiency (within past 28 days) 3. Bilateral infiltrates on frontal chest radiograph 4. Hypoxemia, defined as paO2/FiO2 less than or equal to 250, on any amount of Positive End-Expiratory Pressure (PEEP)
Exclusion criteria
Exclusion criteria: 1. Primary cause of respiratory failure is cardiac 2. Anticipated duration of mechanical ventilation 1 kg per cm body weight) 8. Pregnancy 9. Very unlikely to survive in the judgment of the investigator, and luck of commitment to life support 10. Malignancy or underlying irreversible condition with 6 month mortality greater than or equal to 50% 11. Greater than 48 hours elapsed since first eligible in study hospital 12. Current participation in competing trial 13. Lack of physician, patient or proxy consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mortality attributed to respiratory failure 2. Duration of respiratory failure and duration of mechanical failure 3. Evaluation of respiratory function during mechanical ventilation 4. Incidence of barotrauma 5. Non-respiratory organ dysfunction | — |
Countries
Canada
Outcome results
None listed