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Endometrial injury prior to first cycle IVF/ICSI

The effect of endometrial injury on first cycle IVF/ICSI outcome: a randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN61316186
Enrollment
400
Registered
2015-06-22
Start date
2012-06-01
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Outcome of IVF / ICSI cycles. Pregnancy and Childbirth

Interventions

Endometrial scratch performed in the cycle preceding the IVF/ICSI cycle

Sponsors

Department of Obstetrics and Gynecology
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Age between 20-40 years 2. FSH = 12 3. Normal uterine cavity by hysteroscopy (done routinely for all cases prior to ICSI) 4. = 2 good quality embryos replaced

Exclusion criteria

Exclusion criteria: 1. Age > 40 years 2. Abnormal uterine cavity due to submucous fibroid, endometrial polyps, Asherman’s syndrome or congenital uterine malformations 3. Patients who have < 2 good quality embryos at time of transfer were excluded from the analysis

Design outcomes

Primary

MeasureTime frame
1. Live birth rate; calculated as the ration of number of patients with live births divided by the number of patients who had embryo transfer 2. Implantation rate; calculated as number of gestational sacs evident by ultrasound divided by the number of transferred embryos

Secondary

MeasureTime frame
1. Clinical pregnancy rate; calculated as the number of patients with clinical pregnancy divided by the number of patients who had embryo transfer 2. Miscarriage rate per clinical pregnancy; calculated as the number of patients who had miscarriage divided by the number of patients who had clinical pregnancies 3. Multiple gestations rate; calculated as the number of patients who had multiple gestation divided by the number of patients who had clinical pregnancies 4. Pain; reported pain during the intervention 5. Bleeding; reports of abnormal bleeding during or after the intervention

Countries

Egypt

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 20, 2026