Pneumonia Respiratory Pneumonia
Conditions
Interventions
Vitamin D3 100,000 IU supplementation vs placebo
Sponsors
Aga Khan Health Services Afghanistan (Afghanistan)
Eligibility
Inclusion criteria
Inclusion criteria: Any child, living in the defined areas of Kabul (within the catchment area of the Maywand Teaching Hospital), between 1 week and 18 complete months of age.
Exclusion criteria
Exclusion criteria: 1. >8 hours after the start of hospital antibiotics treatment 2. Living outside of the study areas of Kabul and child?s families expect to move away within the next 3 months 3. If the child has been diagnosed with clinical rickets or known to have received a course of high dose vitamin D treatment in the past 3 months (doses as high as 300,000 IU are used routinely in India and Pakistan, and thus rarely, some recently returned returnee children may have recently received such doses) 4. If have symptoms of very severe pneumonia (according to IMCI definitions of very severe pneumonia) or other illnesses as the major diagnosis occurring at the same time as pneumonia, such as meningitis, major heart or renal defect, active measles, severe malnutrition requiring separate medical treatment, and suspected tuberculosis 5. Child with severe diarrhoea or vomiting 6. Wheeze at the time of diagnosis (if wheeze develops later the child continues to be in the study) 7. Caretakers do not give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of pneumonia as measured from the date of clinical diagnosis and treatment onset to the last date of illness with any of the following criteria: 1. Respiratory rate according to age and IMCI criteria 2. No danger signs or subcostal recession 3. No fever (temperature < 38.0 °C or < 37.50 °C if < 2 month old) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of further episodes within 3 months or relapse of pneumonia (The Integrated Management of Childhood Illness [IMCI] defined rapid breathing and cough) 2. Rate of failure to respond to treatment or worsening condition rate (as defined by protocol) | — |
Countries
Afghanistan
Outcome results
None listed