Does ischaemic preconditioning reduce adverse events following endovascular repair of abdominal aortic aneurysms? A randomised controlled pilot trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN61182546

Enrollment

Registered

2006-08-17

Start date

2006-06-15

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal aortic aneurysm Circulatory System Abdominal aortic aneurysm

Interventions

Intervention: Remote ischaemic preconditioning. After induction of anaesthesia, an inflatable cuff will be used to render each leg ischaemic for ten minutes. The operation will then proceed in the usu

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Any patient undergoing elective endovascular repair of an abdominal aortic aneurysm.

Exclusion criteria

Exclusion criteria: 1. Ankle-brachial pressure index less than 0.7 2. Previous renal transplant 3. Previous renal disease 4. Previous renal replacement therapy 5. Previous endovascular aneurysm repair 6. Baseline serum creatinine more than 150 mmols/l 7. Baseline serum urea more than 20 mmols/l 8. Previous lower limb amputation

Design outcomes

Primary

Measure	Time frame
Urinary retinol binding protein levels pre- and post-operatively.	—

Secondary

Measure	Time frame
1. Urinary albumin-creatinine ratios 2. Urinary Tumour Necrosis Factor (TNF), Tumour Necrosis Factor Receptor (TNFR) 1 and TNFR2 3. Serum TNF, TNFR1 and TNFR2 4. Serum creatinine 5. Creatinine clearance 6. Glomerular filtration rate 7. Cardiac index as measured by the LiDCO system 8. Peripheral vascular resistance as measured by the LiDCO system 9. Ischaemia detected on 12-lead electrocardiogram	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026