Common causes and patient outcomes of community-acquired pneumonia in sub-Saharan Africa

Management of Lower Respiratory Tract Infections in Sub-Saharan Africa, a pragmatic approach

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN61173943

Enrollment

406

Registered

2022-01-31

Start date

2022-01-18

Completion date

Unknown

Last updated

2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Community acquired pneumonia Infections and Infestations

Interventions

Patients hospitalized with community acquired pneumonia will have their sputum tested using conventional culture based tests and this will be compared with multiplex PCR tests to determine the perform

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Clinically diagnosed pneumonia (fever =38°C, with cough, chest pain, breathlessness or hemoptysis) and at least one focal chest sign (crepitations, pleural rub, bronchial breathing, dullness on percussion or diminished breath sounds) for <3 weeks 2. Consent to study participation

Exclusion criteria

Exclusion criteria: 1. Hospitalized in the last 30 days 2. Cancer chemotherapy 3. Have chronic renal failure 4. Treatment for active pulmonary tuberculosis 5. Respiratory failure secondary to severe chronic obstructive lung disease 6. Congestive heart failure

Design outcomes

Primary

Measure	Time frame
Diagnostic test (Biofire FilArray) compared with the gold standard at study enrollment	—

Secondary

Measure	Time frame
Biomarkers (CRP, PCT) compared against Early Treatment failure at day 3 using sputum test	—

Countries

Uganda

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026