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Leptospirosis outcomes across a South East Asian cohort

The case burden, treatment strategies, and patient outcomes for Leptospirosis across South-East Asia; a multi-country cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN61089608
Enrollment
3000
Registered
2025-12-11
Start date
2023-12-19
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Clinical characteristics, treatments, and outcomes of people seen at health institutions with leptospirosis Infections and Infestations

Interventions

Data capture for all participants was from at least the first health services contact until the end of hospital contact or last study contact. Summary statistics were performed as well as risk analysi

Sponsors

Nagasaki University
Lead Sponsor
London School of Hygiene & Tropical Medicine
Collaborator

Eligibility

Sex/Gender
All
Age
1 Years to 87 Years

Inclusion criteria

Inclusion criteria: Clinical or microbiological diagnosis of leptospirosis from a search of hospital records

Exclusion criteria

Exclusion criteria: For SLH2 dataset, the following exclusions were applied: 1. Hospitalization last 30 days 2. Fever onset > 48 hours post-hospitalization 3. Blood culture draw = 48 hours after admission 4. Positive microbiological diagnosis of dengue at admission 5. Diagnosis of other viral infection and WBC = 12,000/mm3 or = 4,000 mm3 6. Known underlying chronic disease/condition 7. < 1 year old 8. Declined consent to participate For BMH1 the following exclusions were applied: 1. Clinical diagnosis of malaria, dengue, food-borne gastroenteritis, cellulitis, or rat-bite fever at admission 2. Microbiological diagnosis at source referral 3. Suspected of having hepatitis-related disease

Countries

Malaysia, Philippines, Viet Nam

Contacts

Public ContactNathaniel Lee
nathaniel.lee@doctors.org.uk+44 (0)20 7636 8636

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026