Exposure to toxic materials Injury, Occupational Diseases, Poisoning
Conditions
Interventions
Volunteers were randomly assigned to each treatment group using an online treatment allocation generator (Urbaniak, G. C., & Plous, S. (2013). Research Randomizer (Version 4.0) [Computer software]. Re
10 mg mL-1) dissolved in methyl salicylate
Sponsors
Intertox Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Volunteers 2. Male or female 3. Age 18 – 60 (at the start of the study)
Exclusion criteria
Exclusion criteria: 1. Allergy to aspirin 2. Currently taking blood-thinning agents (anti-coagulant or anti-platelet) 3. Renal impairment 4. Inflammatory disorder affecting the skin 5. Partially healed/open wounds 6. Respiratory condition (other than controlled asthma) 7. Pregnant or breastfeeding 8. Any other relevant condition at the discretion of an independent physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of the protocol, determined by LC-DAD-MS measurements of the amount of a chemical contaminant (curcumin/methyl salicylate mixture) recovered from the hair and skin of exposed participants in comparison with a control (exposed, untreated) treatment group | — |
Secondary
| Measure | Time frame |
|---|---|
| Semi-quantitative determination of the area of contamination on hair and skin surfaces, observed by fluorescent imaging of exposed participants in comparison with a control (exposed, untreated) treatment group | — |
Countries
United Kingdom
Contacts
Public ContactTracey Thomas
Outcome results
None listed