Overweight/obesity Nutritional, Metabolic, Endocrine Obesity
Conditions
Interventions
This randomized prospective study will include about 40 overweight/obese individuals aged 18-65 years, who will follow a slightly hypocaloric diet for 3 months. Participants were asked not to change t
Sponsors
University of Padua
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Body mass index (BMI) =25 kg/m2 2. Aged 18-65 years 3. Referred to the Endocrinology Unit of the University of Padua for the purpose of losing weight
Exclusion criteria
Exclusion criteria: 1. Smoking 2. Treatment with levothyroxine or any medication modifying thyroid function (e.g. corticosteroids, amiodarone, propranolol, lithium) 3. TSH levels outside the normal laboratory range 4. Severe cardiopathy treated with antiarrhythmics or vasodilators 5. Pregnancy or breastfeeding; previous or current malignancies 6. Severe eating disorders 7. Liver failure 8. Pharmacological treatment for obesity 9. Chronic inflammatory disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body mass composition will be assessed with a bioelectrical impedance analysis (BIA) using the Biavector® nomogram and Bodygram™ software (Akern Bioresearch s.r.l.), recording values for lean mass, fat mass, and muscle mass at baseline and 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Leptin levels will be assessed using blood samples taken at baseline and 3 months 2. Weight will be measured during clinical assessment at baseline and 3 months 3. Mood will be assessed using the Psychological General Well-Being Index (PGWBI) questionnaire at baseline and 3 months 4. Thyroid function will be assessed using blood samples taken at baseline and 3 months | — |
Countries
Italy
Outcome results
None listed