The Hertfordshire Physical Activity Trial

Conditions

Metabolic risk Nutritional, Metabolic, Endocrine

Francis Finucane, Kate Westgate, Stephen P. Sharp, Simon J. Griffin, Martin O’Donnell et al. (9 authors)

BMJ Open Sport & Exercise Medicine2025-01-01

10.1136/bmjsem-2023-001857

Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals.

Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Aihie Sayer A, Cooper C, Griffin SJ, Wareham NJ.

2014-03-2630 citations

10.1186/1758-5996-6-43

The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial.

Finucane FM, Sharp SJ, Purslow LR, Horton K, Horton J, Savage DB, Brage S, Besson H, De Lucia Rolfe E, Sleigh A, Martin HJ, Aihie Sayer A, Cooper C, Ekelund U, Griffin SJ, Wareham NJ.

2010-01-0677 citations

10.1007/s00125-009-1641-z

Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial.

Finucane FM, Horton J, Purslow LR, Savage DB, Brage S, Besson H, Horton K, Rolfe Ede L, Sleigh A, Sharp SJ, Martin HJ, Sayer AA, Cooper C, Ekelund U, Griffin SJ, Wareham NJ.

2009-06-1910 citations

10.1186/1472-6823-9-15

Interventions

Aerobic exercise programme versus care as usual. The control group continue with their normal activities. The exercise group take part in a fully supervised 12- week aerobic exercise programme. There

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers from the Hertfordshire Birth Cohort 2. Male and female, born between 1931 - 1939

Exclusion criteria

Exclusion criteria: 1. Diabetes 2. Untreated hypertension 3. Ischaemic heart disease

Design outcomes

Primary

Measure	Time frame
Clustered Metabolic Risk Score. Study participants return for their second visit thirteen weeks after their baseline visit. The outcomes will be measured at this time.	—

Secondary

Measure	Time frame
1. Body composition 2. Insulin sensitivity 3. Physical fitness Study participants return for their second visit thirteen weeks after their baseline visit. The outcomes will be measured at this time.	—

Countries

England, United Kingdom

Outcome results

None listed