Severe acute malnutrition treatment delivered by community health workers in emergency settings of Mali (iCCM+ Project)

Effectiveness, cost-effectiveness, and coverage of the treatment of severe acute malnutrition delivered by community health workers through a protocol based on simplified approaches in emergency settings of Mali

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN60973756

Enrollment

1728

Registered

2020-10-15

Start date

2020-07-01

Completion date

Unknown

Last updated

2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uncomplicated severe acute malnutrition of children 6 to 59 months Nutritional, Metabolic, Endocrine Malnutrition

Interventions

The study design includes three arms: - Control arm: treatment is provided only in health centers following the national protocol. Admission criteria: Edema +/++ and/or WHZ -1.5 z-score or MUAC >=12

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Children from 6 to 59 months of age 2. Diagnosed with uncomplicated severe acute malnutrition 3. Positive appetite test result 4. Without any medical danger sing (severe oedema, unable to drink or suck, severe vomit, convulsing, non-response to external stimuli, severe palmar pallor, severe difficulty breathing, spontaneous bleeding, dark urine, unable to sit/stand, severe diarrhea/dehydration)

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
Data will be extracted directly from the patient records existing in the health centers and health huts at the end of the study: 1. Recovery rate: proportion of children achieving and maintaining the discharge criteria during two follow-up visits (two consecutive weeks) 2. Default rate: proportion of children absent of two follow-up visits (two consecutive weeks) 3. Decease rate: proportion of children who die during treatment or in transit to inpatient care 4. Referral rate: proportion of children referred to inpatient care due to the appearance of medical complications or nutritional treatment failure (non-response considered as oedema still present after 21 days, weight loss for two consecutive visits, not weight gain in 14 days, or failure in the appetite test)	—

Measure

Time frame

Data will be extracted directly from the patient records existing in the health centers and health huts at the end of the study: 1. Recovery rate: proportion of children achieving and maintaining the discharge criteria during two follow-up visits (two consecutive weeks) 2. Default rate: proportion of children absent of two follow-up visits (two consecutive weeks) 3. Decease rate: proportion of children who die during treatment or in transit to inpatient care 4. Referral rate: proportion of children referred to inpatient care due to the appearance of medical complications or nutritional treatment failure (non-response considered as oedema still present after 21 days, weight loss for two consecutive visits, not weight gain in 14 days, or failure in the appetite test)

—

Secondary

Measure	Time frame
1. Coverage compared at baseline and end-line from two population-based surveys conducted at the beginning and end following the standardized SLEAC methodology 2. Cost-effectiveness: cost per child treated and cost per child recovered. Financial information for the cost-effectiveness analysis will be taken towards the middle of the recruitment period using as a source the logistics and financial records of the Action Against Hunger offices and the health district authorities Obtained monthly from the patient records: 3. Severity at admission (MUAC and WHZ measurements and oedema proportion) 4. Recovery time: time spent in treatment until being discharged as cured 5. Number of follow-up visit absent in those children recovered 6. Number of RUTF sachets consumed by those children recovered 7. Average weight and MUAC gain of those children recovered 8. Number of cases treated for other non-severe common diseases in an integrated manner (diarrhea, malaria, acute respiratory infection)	—

Measure

Time frame

1. Coverage compared at baseline and end-line from two population-based surveys conducted at the beginning and end following the standardized SLEAC methodology 2. Cost-effectiveness: cost per child treated and cost per child recovered. Financial information for the cost-effectiveness analysis will be taken towards the middle of the recruitment period using as a source the logistics and financial records of the Action Against Hunger offices and the health district authorities Obtained monthly from the patient records: 3. Severity at admission (MUAC and WHZ measurements and oedema proportion) 4. Recovery time: time spent in treatment until being discharged as cured 5. Number of follow-up visit absent in those children recovered 6. Number of RUTF sachets consumed by those children recovered 7. Average weight and MUAC gain of those children recovered 8. Number of cases treated for other non-severe common diseases in an integrated manner (diarrhea, malaria, acute respiratory infection)

—

Countries

Mali

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026