Sepsis Infections and Infestations Sepsis
Conditions
Interventions
1. Most patients participating in the study will be mentally incapacitated due to the influence of strong sedating drugs and underlying critical illness
2. Before the incapacitated patient is enrolled
Sponsors
James Cook University Hospital (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 28 Adult patients (>18 years old) 2. Have severe sepsis or septic shock, as defined by the International Sepsis Definitions Conference (Levy MM et al, 2003) 3. Are equipped with both arterial and central line 4. In whom CO monitoring and an intervention to increase stroke volume (SV) and hence CO (e.g. fluid bolus, inotropes) is deemed necessary
Exclusion criteria
Exclusion criteria: 1. No consent: objection from somebody close who is willing to be consulted about the appropriateness of the patient being enrolled in the study in line with the Mental Capacity Act objection through registered lasting power of attorney for medical affairs advance ecision precluding research retrospective withdrawal of consent 2. Pregnancy 3. Age below 18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between changes of cardiac output with changes in central venous saturation and central venous arterial partial pressure of carbon dioxide difference, respectively | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity and specificity of pulse pressure and stroke volume variation to predict an increase in cardiac output by at least 10% | — |
Countries
United Kingdom
Outcome results
None listed