The effect of prehabilitation on the outcome of anterior cruciate ligament reconstruction

The effect of prehabilitation on the outcome of anterior cruciate ligament reconstruction: a two centre prospective, single surgeon, randomly allocated study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN60779921

Enrollment

Registered

2011-01-31

Start date

2011-01-13

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior cruciate ligament tear Injury, Occupational Diseases, Poisoning Knee injury

Interventions

This interventional trial will recruit 30 patients: 15 in the prehabilitation exercise group, 15 control patients recieving standard pre- and post-operative care. The prehabilitation group will reciev

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Patients with isolated anterior cruciate ligament tear 2. Males aged 18 - 40 years

Exclusion criteria

Exclusion criteria: 1. Patients with age less than 18 or over 40 years 2. Patients living outside Greater Dublin area (for practical reasons regarding exercise supervision) 3. Patients with associated fractures, meniscal repair and collateral ligament injury 4. Patients with co-morbidities (contra-indication to relatively high physical exertion)

Design outcomes

Primary

Measure	Time frame
1. Isokinetic quadriceps strength testing 2. Magnetic resonance imaging cross-sectional area of the quadriceps (MRI CSA) 3. Physical performance test: single leg hop test and in-line lunge 4. Disease specific questionnaire: Modified Cincinnatti Knee Score, Tegner Lysholm Knee Score, Tegnaer Activity Scale 5. Muscle biopsy of quadriceps: looking for down-regulation of muscle atrophy genes and up-regulation in IGF-1 pathways in muscle hypertrophy Patients will undergo all the above test at time of recruitment, 6 weeks post exercise and 3 months postoperatively. 6. Time to return to sports activities	—

Measure

Time frame

1. Isokinetic quadriceps strength testing 2. Magnetic resonance imaging cross-sectional area of the quadriceps (MRI CSA) 3. Physical performance test: single leg hop test and in-line lunge 4. Disease specific questionnaire: Modified Cincinnatti Knee Score, Tegner Lysholm Knee Score, Tegnaer Activity Scale 5. Muscle biopsy of quadriceps: looking for down-regulation of muscle atrophy genes and up-regulation in IGF-1 pathways in muscle hypertrophy Patients will undergo all the above test at time of recruitment, 6 weeks post exercise and 3 months postoperatively. 6. Time to return to sports activities

—

Secondary

Measure	Time frame
1. To determine the effect of a pre-operative exercise programme on isokinetic hamstring strength 2. To assess the validity, reliability and responsiveness of: 2.1. Isokinetic dynamometry 2.2. Physical performance tests 2.3. Questionnaires	—

Countries

Ireland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026