Suspected acute stroke Circulatory System Stroke, not specified as haemorrhage or infarction
Conditions
Interventions
This research project is a prospective observational cohort study to determine whether blood concentrations of d-dimer and/or whole blood purine can predict the presence of large vessel occlusion stro
Sponsors
Northumbria Healthcare NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or over 2. Arrived at the study hospital by emergency ambulance 3. New acute stroke suspected by ambulance personnel before hospital arrival 4. At least responsive to tactile stimuli (i.e. A, V or P on the AVPU scale) on hospital arrival 5. New suspected stroke symptoms are still present when taking blood measurements 6. Blood sampling can be undertaken within 6 hours of suspected stroke symptom onset/last known well (times determined by hospital specialist staff) 7. Blood sampling can be undertaken prior to any reperfusion treatments 8. Routine brain imaging is intended to be urgently performed
Exclusion criteria
Exclusion criteria: 1. Already assessed at another hospital and ambulance admission is a transfer for continuing care 2. Hypoglycaemia (capillary glucose <3.5 mmol/l) 3. External signs of significant acute trauma which are likely to need additional treatment (large haematomas, open wounds, limb deformity) 4. Assigned a recent previous (within the last 4 weeks) diagnosis likely to have resulted in elevated D-dimer levels i.e. deep vein thrombosis, pulmonary embolism, arterial embolism, stroke, long bone fracture, major trauma, any surgery under general anaesthesia 5. Chemotherapy or radiotherapy treatment for cancer within the last 7 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the Receiving Operating Curve (ROC), sensitivity, specificity, negative and positive predictive values for identification of LVO stroke calculated from blood values and reference standard tests | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the Receiving Operating Curve (ROC), sensitivity, specificity, negative and positive predictive values for identification of any stroke calculated from blood values and reference standard tests | — |
Countries
England, United Kingdom
Outcome results
None listed