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The efficacy of e-cigarettes compared with nicotine replacement therapy, when used within the UK stop smoking service

A randomised controlled trial to examine the efficacy of e-cigarettes compared with nicotine replacement therapy, when used within the UK stop smoking service

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN60477608
Enrollment
886
Registered
2015-04-07
Start date
2015-04-15
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking cessation Mental and Behavioural Disorders Mental and behavioural disorders due to use of tobacco

Interventions

Smokers who want help to quit smoking will be individually randomised to receive usual care (UC
a choice of NRT combined with usual care behavioural support provided by a Stop Smoking Service) or EC with the same behavioural support.

Sponsors

Queen Mary University of London (QMUL)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18 or over 2. Current smoker accessing the stop smoking service 3. Able to read/write/understand English

Exclusion criteria

Exclusion criteria: 1. Pregnant or breastfeeding 2. Strong preference to use or not to use NRT or EC in their quit attempt 3. Enrolled in other interventional research 4. Currently using NRT or EC

Design outcomes

Primary

MeasureTime frame
Carbon monoxide (CO) validated sustained abstinence rates at 52 weeks post–target quit date (TQD)

Secondary

MeasureTime frame
1. CO validated sustained abstinence rates at 4 and 24 weeks post–TQD 2. 7-day point prevalence abstinence at 4, 24 and 52 weeks 3. Smoking reduction in participants who did not achieve full abstinence 4. Treatment ratings 5. Adverse reactions 6. Cost-efficacy of the interventions

Countries

England, United Kingdom

Contacts

Public ContactAnna Phillips
a.phillips@qmul.ac.uk+44 (0)207 882 5747

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 22, 2026