Is a vitamin and mineral supplement containing a small amount of iron as useful as one with a higher amount of iron in supporting the health of Bangladeshi children living in areas with a high level of iron in drinking water sources?

Efficacy of Micronutrient Powder (MNP) with low-dose of iron in Bangladeshi children living in areas with a high level of iron in groundwater

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN60058115

Enrollment

327

Registered

2019-07-03

Start date

2018-10-18

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Iron deficiency anaemia Circulatory System Iron deficiency anaemia

Interventions

The study is a randomized controlled trial in a community setting in rural Bangladesh. At the screening, the children aged 22-54 months were selected if the concentration of iron of the water of the t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Children aged 24-53 months 2. Children drinking from groundwater with a high level of iron (>=2 mg/L) 3. Guardians willing for children to participate

Exclusion criteria

Exclusion criteria: 1. Children receiving antibiotic in the preceding 2 months of the enrollment. 2. Children receiving MNP or other iron supplements in the preceding 2 months of the enrollment. 3. Children with any congenital or chronic debilitating ailment. 4. Mother and the head of the household not willing to allow their child to participate in the trial.

Design outcomes

Primary

Measure	Time frame
1. Haemoglobin level in blood at baseline and endline (2 months after the start of treatment) 2. Serum ferritin level at baseline and endline (2 months after the start of treatment) 3. Soluble transferrin receptor (sTfR) level in blood at baseline and endline (2 months after the start of treatment) 4. Composition of gut microbiota from analysis of stool sample at baseline and endline (2 months after the start of treatment) 5. Incidences of morbidity, e.g. diarrhea, vomiting, respiratory infections, etc monitored weekly throughout the intervention until endline (2 months after the start of treatment)	—

Measure

Time frame

1. Haemoglobin level in blood at baseline and endline (2 months after the start of treatment) 2. Serum ferritin level at baseline and endline (2 months after the start of treatment) 3. Soluble transferrin receptor (sTfR) level in blood at baseline and endline (2 months after the start of treatment) 4. Composition of gut microbiota from analysis of stool sample at baseline and endline (2 months after the start of treatment) 5. Incidences of morbidity, e.g. diarrhea, vomiting, respiratory infections, etc monitored weekly throughout the intervention until endline (2 months after the start of treatment)

—

Secondary

Measure	Time frame
1. Nutritional status assessed by measuring the weight and height of the children at baseline and endline (2 months after the start of treatment)	—

Countries

Australia, Bangladesh

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 23, 2026