Dementias and Neurodegenerative Diseases Research Network Mental and Behavioural Disorders Huntington's Disease
Conditions
Interventions
1. Participants will be allocated to an intervention or a control group
2. Those allocated to the intervention group will be asked to exercise once a week in a community based gym under supervision of
Sponsors
Cardiff University (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The diagnosis of Huntington's Disease (HD), confirmed by genetic testing and neurological examination (this is a routine requirement for any of the participants enrolled in the Registry study) 2. The ability to walk independently as primary means of mobility and willing to travel to the exercise centre for the intervention 3. The capacity to give informed consent 4. A total functional capacity (TFC) score of at least 7 5. A Unified Huntington's Disease Rating Scales (UHDRS) Transcranial Magnetic Stimulation (TMS) score of at least 5 6. Have maintained a stable medical regime for 4 weeks prior to initiation of study and are able to maintain a stable regime for the course of the study 7. Either gender
Exclusion criteria
Exclusion criteria: 1. Have a history of additional prior major neurological condition, such as stroke 2. Have an orthopaedic condition that independently limits mobility 3. Have cardiac precautions that would prevent the subject from completing the exercise programme or completing the full battery of outcome measures 4. Demonstrate uncontrolled psychiatric symptoms 5. Are pregnant 6. Demonstrate any contraindication to exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A number of outcomes that are representative of participation restriction, activity limitation as | — |
Countries
United Kingdom
Outcome results
None listed