Stroke Circulatory System Cerebral infarction
Conditions
Interventions
Baseline assessments include:
1. The Mini Mental State Examination: the MMSE is a brief screening tool to provide quantitative assessment of cognitive function. It consists of 11 simple questions or t
orientation to time, orientation to place, registration of three words, attention and calculation.
2. Edinburgh Handedness Inventory: this is a brief questionnaire of 10 short items, which determines
Sponsors
Oxford Brookes University (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients will be selected from those treated in the Oxford Radcliffe Hospitals who are: 1. More than 6 months following a first stroke 2. Both males and females, aged 45 to 80 years 3. With an ischaemic infarct upon computed tomography (CT) or magnetic resonance imaging (MRI) scan 3. Able to perform a simple reciprocal bilateral foot tapping task, walk safely on a treadmill with or without mobility aids 4. Be able to give informed consent Sex and age-matched controls will be chosen who do not have a known neurological disease, a history of hypertension, cardiac disease or diabetes.
Exclusion criteria
Exclusion criteria: 1. Dementia 2. Aphasia significantly limiting communication 3. History of previous symptomatic strokes or neurological disease 4. Known psychiatric disease or claustrophobia, or other conditions precluding safe MRI (e.g., pacemaker or other metal implant)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Task-related changes in oxygenated and deoxygenated haemoglobins in the frontal lobe as measured by NIRS. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rate of backward calculation (number per minute) 2. Number of errors in backward calculation (errors per trial) 3. Spatiotemporal gait measures (speed, cadence, step time, stride time, step length, stride length, step width) | — |
Countries
United Kingdom
Outcome results
None listed