Helicobacter pylori infection Infections and Infestations Helicobacter pylori infection
Conditions
Interventions
The treatment group received a triple H. pylori eradication regimen consisting of 20 mg esomeprazole, 1,000 mg amoxicillin and 500 mg clarithromycin, twice daily for 7 days. The control group received
Sponsors
Inje University, Ilsan Paik Hospital (Korea, South)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers with H. pylori infection, who saw a poster describing the study and wanted to participate.
Exclusion criteria
Exclusion criteria: 1. Age 70 years 2. Pregnancy 3. Abnormal gastric lesion, including ulcer and cancer 4. Duodenal ulcer 5. Liver disease 6. Renal impairment 7. Previous gastrointestinal surgery 8. History of H. pylori eradication 9. Drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ghrelin mRNA levels in gastric mucosa at baseline and 5 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| The following were assessed at baseline and 5 weeks: 1. Obestatin and TNF-a mRNA of gastric mucosa 2. Plasma ghrelin, obestatin and ghrelin/obestatin ratio | — |
Countries
Korea, South
Outcome results
None listed