Obesity Nutritional, Metabolic, Endocrine Obesity
Conditions
Interventions
Control:
1. Reduce physical activity to < 4000 pedometer steps per day for 7 days
2. Increase energy intake by 50% above normal for 7 days
Intervention:
1. Reduce physical activity to < 4000 pedome
Sponsors
University of Bath (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male, aged 18 to 40 2. Physically active (more than 30 minutes per day 5 days per week) 3. Weight Stable (over the past 6 months)
Exclusion criteria
Exclusion criteria: 1. Females 2. Smoker 3. Age outside range 4. Positive responses to Physical Activity Readiness Questionnaire 5. Taking medication 6. Doctor diagnosed condition that might interact with study measures (e.g. cardiovascular disease)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in insulin sensitivity and glycaemic control. Measured at baseline and at the end of the intervention (i.e., after 7 days). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Other blood measures related to metabolic function and inflammation (e.g., cholesterol, Non-Esterified Fatty Acids [NEFA], Triacylglycerol, alanine aminotransferase [ALT], interleukin (IL)-6, leptin, adiponectin) 2. Changes in adipose tissue gene expression related to metabolic function and inflammation Measured at baseline and at the end of the intervention (i.e., after 7 days). | — |
Countries
United Kingdom
Outcome results
None listed