Influence of heart rate reduction on heart injury that happens during interventional coronary procedure and stent deployment in patients with coronary disease

Effect of heart rate reduction on periprocedural myocardial injury and angina symptoms in elective patients with coronary disease undergoing coronary intervention

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN59609019

Enrollment

Registered

2018-07-06

Start date

2010-05-17

Completion date

Unknown

Last updated

2021-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic heart disease with stable angina Circulatory System

Interventions

After inclusion criteria were met patients were invited to participate in study. Informed consent was obtained, and patients were instructed to attend first visit one month before planned procedure. A

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective PCI 2. Suspected or established coronary artery disease 3. Presence of sinus rhythm 4. Resting heart frequency above 70 beats per minute

Exclusion criteria

Exclusion criteria: 1. Previous pacemaker implantation 2. Symptoms and signs of heart failure 3. Ejection fraction of left ventricle below 50% 4. Levels of creatinine above upper level of normal (ULN) 5. Already treated with ivabradine

Design outcomes

Primary

Measure	Time frame
Periprocedural myocardial injury, measured using cardiac troponin I assay (Siemens Healthcare Diagnostics) from blood samples at admission (before the procedure) and 24 hours after the procedure	—

Secondary

Measure	Time frame
Symptoms of angina, assessed with the number of angina attacks (chest pain) per week, on the day of inclusion and 1 month after the inclusion	—

Countries

Slovenia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026