Fibroadenoma Cancer Breast cancer
Conditions
Interventions
Goal:
To determine the impact of one cycle of a combined oral contraceptive on breast homeostasis, we evaluated the Proliferation Index (PI), determined by the expression of KI-67, in normal human ma
Sponsors
Federal university of Sao Paulo (Universidade Federal de Sao Paulo) (Brazil)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Females between 14 to 36 years of age 2. Undergoing excision of Fibroadenomas (FA) (a condition thought not to be associated with an increase risk of cancer) at the Department of Gynecology, Mastology Division: Benign mammary diseases, Federal University of São Paulo, Paulista Medical School 3. Signed an informed consent before enrolment in the study 4. Regular menstrual cycles (intervals of 28 ± two days) in the previous six months 5. A known date of the last menstrual period
Exclusion criteria
Exclusion criteria: 1. Use of hormone therapy in the previous 12 months 2. Pregnancy 3. Breast feeding during the previous 12 months 4. Any endocrine disorder 5. Taking any medication at the time that tissue for the study was obtained
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Successful excision of fibroadenoma; the histologically normal tissue (at least 1 cm away from the FA) was studied in women with COC and with natural cycles during the first, second, third and fourth week of the menstrual cycle. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Brazil
Outcome results
None listed