Cognitive mechanisms of change in delusions

Cognitive mechanisms of change in delusions: a multicentre randomised investigation of two experimental interventions

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN59501939

Enrollment

200

Registered

2010-05-28

Start date

2009-03-20

Completion date

Unknown

Last updated

2018-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Mental Health Research Network

Interventions

1. Computer package: designed to change particular thinking styles 2. Manipulating anxiety: to investigate the impact on cognitive processes associated with paranoia Both interventions have an active

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Psychosis, non-affective (International Classification of Diseases version 10 [ICD-10], chapter F2) 2. Current delusion on Schedules for the Clinical Assessment in Neuropsychiatry (SCAN) (for study 2: a persecutory delusion) 3. Rated greater than 0 on visual analogue distress 4. Aged 18 - 65 years, either sex 5. Symptoms stable (no major relapse or crisis in last 3 months) before allocation 6. Sufficient grasp of English to complete measures and participate in manipulations

Exclusion criteria

Exclusion criteria: 1. Primary diagnosis of alcohol or drug dependency 2. Organic syndrome 3. Learning disability

Design outcomes

Primary

Measure	Time frame
Change in anxiety and cognitive processes associated with paranoia, measured immediately post-intervention.	—

Secondary

Measure	Time frame
Change in thinking style and cognitive processes associated with unusual and distressing beliefs, measured immediately post-intervention.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026