Cognitive deficits following cardiopulmonary bypass Injury, Occupational Diseases, Poisoning Brain injury
Conditions
Interventions
Randomisation to maintenance of body and brain temperature constant at 34 °C or 37 °C during the entire intra-operative period. Eleven tests were combined into three cognitive domains:
1. Memory
2. A
Sponsors
University of Ottawa Heart Institute (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Male or female 60 years or older undergoing coronary artery surgery utilising cardiopulmonary bypass.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery 2. Unable to undergo cognitive testing (visual or motor problems, unable to speak French or English) 3. Mini Mental State Examination (MMSE) less than 24 (dementia) 4. Patients undergoing other cardiac procedures in addition to coronary artery bypass graft (CABG) or reoperation 5. Patients with Parkinson's disease or a history of stroke 6. Age less than 60 7. Patients with renal insufficiency (creatinine 2 x normal) or hepatic insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of cognitive deficits at 5 - 7 days after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of cerebral emboli during cardiopulmonary bypass (CPB) as measured by trans-cranial doppler 2. Quality of life at 3 months and the incidence of cognitive deficits at 3 months | — |
Countries
Canada
Outcome results
None listed