Reversal of the respiratory effect of morphine and morphine-6-glucuronide by naloxone: a clinical study using healthy volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN59442355

Enrollment

Registered

2006-07-04

Start date

2005-01-01

Completion date

Unknown

Last updated

2021-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory depression by opioids Respiratory Respiratory depression

Interventions

Measurement of respiration on a breath-to-breath basis. We will study four groups, with 12 subjects per group: 1. Group one will receive M6G 0.2 mg/ kg 2. Group two wil

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy volunteers over 18 years of age

Exclusion criteria

Exclusion criteria: 1. Obesity (Body Mass Index [BMI] more than 30) 2. Presence of medical disease (heart, lung, liver, kidney, neurological disease, diabetes, pyrosis, diaphragmatic hernia) 3. Presence of psychiatric disease 4. History of chronic alcohol or drug use 5. Allergy to study medications 6. Possibility of pregnancy 7. Lactating females

Design outcomes

Primary

Measure	Time frame
Minute ventilation and pain response to heat pain	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026