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Comparison of intravenous magnesium sulphate and intravenous esmolol in attenuating hemodynamic stress response during tracheal extubation

Comparison of intravenous magnesium sulphate and intravenous esmolol in attenuating hemodynamic stress response during tracheal extubation in patients undergoing surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN59382278
Enrollment
80
Registered
2025-10-07
Start date
2021-02-23
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Haemodynamic stress response during tracheal extubation Circulatory System

Interventions

After surgery, operated patients were randomly assigned to groups A and B, with 40 individuals in each group using a computer-generated randomized table. After randomisation, Group A received IV esmol

Sponsors

Era's Lucknow Medical College and Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. ASA Grade-I and Grade-II patients, age 20-55 years, weight 40-75 kg 2. Patients undergoing surgery under General Anaesthesia, who will be extubated at the end of surgery

Exclusion criteria

Exclusion criteria: 1. Patients with an allergy to study drugs 2. Patients with ASA grade 3 or more 3. Patients taking any adrenergic or psychotropic drugs 4. Patients with hepatic or renal disease 5. Patients with lung disease such as COPD

Design outcomes

Primary

MeasureTime frame
SBP, DBP, MAP and HR measured using a blood pressure cuff at baseline, at the time of intervention, 5, 10, and 15 minutes post-intervention

Secondary

MeasureTime frame
SBP, DBP, MAP and HR measured before giving the drug using a blood pressure cuff, at the time of intervention, 5, 10 and 15 minutes post-intervention in both parallel study groups

Countries

India

Contacts

Public ContactAsad Khalid
asadkhalid@gmail.com+91 9452810007

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026