Testing whether taking aspirin before surgery can help prevent blood clots in people having orthopaedic operations

Pre-operative ASpirin for Thromboembolism prophylaxis (PAST) trial: A phase II open-label single-arm trial to evaluate the efficacy and safety of aspirin in preventing thromboembolism in patients undergoing orthopaedic surgery

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN59381053

Enrollment

200

Registered

2026-03-10

Start date

2026-03-08

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preventing thromboembolism in patients undergoing orthopedic surgery Surgery

Interventions

Patients will be administered aspirin (100 mg ) as per protocol, starting within 12 hours pre-surgery stat dose of 100 mg. then 100 mg BID for the next 30 days post operation. Adherence to the medicat

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-90 years 2. Scheduled for elective or emergency orthopedic surgery (hip replacement, knee replacement, spine, and tumor procedures) 3. Able and willing to provide informed consent 4. No contraindications to aspirin use (e.g., active bleeding disorders, aspirin allergy)

Exclusion criteria

Exclusion criteria: 1. Pre-existing DVT or pulmonary embolism 2. Current use of other anticoagulants or antiplatelet agents 3. Significant renal or hepatic insufficiency 4. Pregnancy or breastfeeding

Countries

Oman

Contacts

Public ContactMuhannad ALOthmani

r23126@resident.omsb.org+968 96774848

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026