Comparison of two different techniques to visualize narrowing of coronary arteries using cardiac MRI: the SPARSE perfusion study

Comparison of compressed sensing-based gradient echo perfusion sequence and conventional gradient echo sequence in assessment of myocardial ischemia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN59354874

Enrollment

Registered

2019-04-30

Start date

2015-04-01

Completion date

Unknown

Last updated

2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease Circulatory System

Interventions

Participants receive two adenosine-stress myocardial MR scans (one for each tested perfusion sequence*) and a coronary angiography as reference standard within six weeks. On both MR scans, coronary pe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Planned invasive coronary angiography due to clinical suspection of coronary artery disease 2. Age at least 18 years (no upper limit)

Exclusion criteria

Exclusion criteria: 1. Any contraindication for contrast-based MRI or adenosine 2. Chronic renal failure (glomerular filtration rate < 30ml/min) 3. Previous participation in this study 4. Persistent or permanent atrial fibrillation 5. Coronary Intervention within 30 days before study inclusion 6. Myocardial infarction within 6 months before inclusion

Design outcomes

Primary

Measure	Time frame
Detection of stenosis by visual assessment of myocardial perfusion by two blinded readers for each MR scan.	—

Secondary

Measure	Time frame
Semi-quantitative perfusion analysis for both MR scans using two methods: upslope myocardial perfusion reserve and fermi deconvution model	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026