Timing of nutrition in emergency laparotomy

Timing Of Nutrition In emergenCy laparotomy (TONIC) – A randomised trial comparing early parenteral nutrition vs standard nutritional care in adults undergoing emergency laparotomy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN59200516

Enrollment

898

Registered

2026-01-30

Start date

2026-03-16

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hospital complications in adults undergoing emergency laparotomy Surgery

Interventions

Early PN through central venous catheter (CVC) or PICC, commencing within 48 hours of emergency laparotomy/laparoscopy, with biochemistry monitoring as per NICE Clinical Guideline 32. PN is prescribed

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged =18 years 2. Scheduled for NELA eligible expedited, urgent or immediate emergency laparotomy or laparoscopy according to National Confidential Enquiry into Patient Outcome and Death (NCEPOD) criteria 3. Able to give informed consent, with interpreters where necessary OR personal consultee/legal representative provides assent/consent if a patient temporarily lacks capacity

Exclusion criteria

Exclusion criteria: 1. Undergoing trauma-related laparotomy or laparoscopy 2. Being treated with palliative/end of life intent 3. Abdominal surgery in the preceding 30 days 4. On long term PN prior to admission

Countries

England, Scotland, United Kingdom, Wales

Contacts

Public ContactGeorgia Mitchell

tonic@trials.bham.ac.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 7, 2026